Aside from being called “The Mother of All Hormones” Pregnenolone(P5) has been found to regulate brain functions that can help with anxiety and depression. There are over 6,400 articles written about its benefits on several different forms of Anxiety. It’s two downstream metabolites; Progesterone and Allopregnanolone together as a group, provide for neuro-protection, neuro-stimulation, synaptogenesis, free radical scavenging, and increase GABA production. GABA is the natural valium of the brain. Those with low to low-normal P5 have insomnia or poor sleep.